Leopard Gecko acting stangely

Hi everyone I would really appreciate some advice is possible. I have had my leopard Gecko Seth for a few months now and up until the last week or so everything has been fine. He has always been very nervous and spends most of the time in his warm hide where the temperature is around 85-90 degrees. He eats a few meal worms a day but only if I put them right by his door! He also has a moist hide in between and a hide in the cool corner too.

A week or so ago I cleaned out his tank as I usually do and since then he has changed completely. He is constantly out of his hide - just sitting in the corner of the tank during the day. And at night he just climbs everything and tries to escape. If put my hand in now he climbs straight on it and up my arm where before he would go anywhere near me and disappeared into his hide if he so much as saw me. He lets me handle him now with no signs of stress. I wouldnt normally be worried about this except the fact its such a sudden change and also due to the fact that he seems to now have lost interest in food too and hasnt eaten for week or so. He is still pooping as usual.

Does anyone have any ideas what might be happening?

Many thanks.

Difficult to say... a few things I would check, to make certain nothing is wrong:
- floor temp on warm spot
- ambient temp in tank

Also, did you use any chemicals when cleaning that could have left fumes?

Hello there and thanks for replying - nope all I did was rinse the hides out in warm water - used no chemicals at all. Floor temp in warm hide is 90 same as it always is. The weather generally here is a little bit warm and humid at the moment. To be honest he doesnt seem stressed or anything - in fact its the opposite hes a lot more friendly than usual. If it wasnt for the fact that he has stopped eating I wouldnt really be too worried!

Ha, I have no idea then, other than maybe the natural weather is affecting his behavior/appetite. I would not be worried about the eating unless he starts dropping weight. A gram scale could help you monitor more closely, but you could also eyeball it. My lizards occasionally go on hunger strikes. Of course, they are always verging on a little chubby.

It could be that you're starting to see his personality come out after a few months of shy adjustment period too.

If he continues not eating, starts getting thin, etc., I would suggest a check for parasites.